Watson's other films include The Boxer (1997), Angela's Ashes (1999), Gosford Park (2001), Punch-Drunk Love (2002), Red Dragon (2002), The Life and Death of Peter Sellers (2004), Corpse Bride (2005), Miss Potter (2006), Synecdoche, New York (2008), Oranges and Sunshine (2010), War Horse (2011), The Theory of Everything (2014), Kingsman: The Golden Circle (2017), God's Creatures (2022), and Small Things like These (2024).
She was nominated for a Primetime Emmy Award and a Golden Globe Award for her role in the HBO miniseries Chernobyl. She won the British Academy Television Award for Best Actress for playing Janet Leach in the 2011 ITV television biopic Appropriate Adult. She was nominated for the International Emmy Award for Best Actress for the 2017 BBC miniseries Apple Tree Yard. In 2024, she portrayed the lead role of Valya Harkonnen in the HBO science fiction series Dune: Prophecy.