García Bernal was nominated for a BAFTA Award for Best Actor in a Leading Role for his portrayal of a young Che Guevara in The Motorcycle Diaries in 2005, and in 2016 won his first Golden Globe Award for Best Actor – Television Series Musical or Comedy for Mozart in the Jungle. He and fellow actor Diego Luna founded the production company Canana Films in Mexico City. In 2016, Time magazine named him in the annual Time 100 Most Influential People list. In 2020, The New York Times ranked him No. 25 in its list of the 25 Greatest Actors of the 21st Century.
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