In 2001, Hawke was cast as a rookie police officer in Training Day, for which he received a Screen Actors Guild and Academy Award nomination in the Best Supporting Actor category. Other films have included the science fiction feature Gattaca (1997), the title role in Michael Almereyda's Hamlet (2000), the action thriller Assault on Precinct 13 (2005), and the crime drama Before the Devil Knows You're Dead (2007).
Hawke has appeared in many theater productions including The Seagull, Henry IV, Hurlyburly, The Cherry Orchard, The Winter's Tale and The Coast of Utopia, for which he earned a Tony Award nomination. He made his directorial debut with the 2002 independent feature Chelsea Walls. In November 2007 Hawke directed his first play, Jonathan Marc Sherman's Things We Want. Aside from acting, he has written two novels, The Hottest State (1996) and Ash Wednesday (2002). Between 1998 and 2004, Hawke was married to actress Uma Thurman.