Isabelle's big break came when she played Esther in Orphan (2009), which landed her critical acclaim and was hailed as "one of the most momentous examples of acting from a child performer in years." She has won the role of Clove in The Hunger Games (2012), the big-screen adaptation of literary sensation The Hunger Games. That went on to become one of the highest-grossing movies ever with over $407 million at the domestic box office.
Isabelle has been featured in spreads for magazines such as Vanity Fair, Nylon, Marie Claire, Teen Vogue, V, H, Bust and Last magazine.