Brody has also starred in The Thin Red Line(1998), The Village (2004), King Kong (2005), Hollywoodland (2006), Cadillac Records (2008), Predators (2010), and See How They Run(2022). He has frequently collaborated with filmmaker Wes Anderson, appearing in his films The Darjeeling Limited (2007), Fantastic Mr. Fox(2009), The Grand Budapest Hotel (2014), The French Dispatch (2021), and Asteroid City(2023). He portrayed Salvador Dalí in Woody Allen's Midnight in Paris (2011) and Arthur Miller in Andrew Dominik's Blonde (2022).
On television, he has played Luca Changretta in the fourth season of the BBC series Peaky Blinders (2017) and Pat Riley in the HBO sports drama series Winning Time: The Rise of the Lakers Dynasty (2022–2023). He earned Primetime Emmy Award nominations for his roles as Harry Houdini in the History Channel miniseries Houdini (2014), and investor Josh Aaronson in the HBO series Succession (2021).